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Up to few years ago, cell communication was thought to be exclusively regulated through cell-cell junctions or via exchange of soluble molecular factors. But several “nanoscale” ways, maintained within a membrane boundary, are today featuring strongly. They include membranous nanoparticles named extracellular nanovesicles (EVs) and tunneling nanotubes, which are “made by cells for cells”. Their function is to transport lipids, proteins and nucleic acids, and they stand out for their precision and targeting capacity, which is achieved thanks to the unique composition and structure of their membrane (which to date is inaccessible to synthetic mimics).
This non-incremental technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and clinical translation, impacting life quality for people. Major objectives include: (i) production high-grade EVs with biomimetic and organotropic functions, (ii) synthesis and functionalization of MBDs, (iii) engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs) (iv) evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo.